Welcome!
ALERT Event: Nanoscopy Imaging Using STED 3X Technology – Achieving Resolutions Down to 30nm (Registry Required)
Date: Friday, Nov. 22nd. Time: 11:00 AM – 12:00 PM
Location: Biomedical Research Building, Room 105
Overview:
The seminar will cover the fundamentals and capabilities of STED 3X Nanoscopy and Confocal Super-Resolution technology. STED (Stimulated Emission Depletion) allows for super-resolution imaging purely through optical means, built on a confocal platform. Using the Leica TCS SP8 system, you can achieve 30nm XY and 130nm Z resolutions in STED mode, as well as 140nm XY and 300nm Z resolutions in confocal super-resolution mode, all powered by Leica’s exclusive White Light Laser (tunable from 470–670 nm) in a single system.
Hands-On Training (Registry Required):
Following the seminar, we'll be hosting four one-hour training sessions for STED users from 1:00 PM to 5:00 PM. Due to time constraints, each session will be limited, but it's a fantastic opportunity for our local imaging community.
Please register here. We look forward to seeing you there!
(hide this warning on this page)The Athymic Animal & Xenograft Core consists of two physical sites, one at Case Western Reserve University and one at Cleveland Clinic at the Taussig Cancer Institute. The purpose of the core is to help principal investigators of CWRU and Cleveland Clinic perform tumor experiments, angiogenesis studies, and pharmacokinetic studies in mice. The Core routinely conducts animal experiments involving several syngeneic murine tumor models, and several human xenograft (athymic nude mouse, and NSG – NOD scid IL2Rg mouse) tumor models. In addition, the Core has developed several orthotopic tumor models: brain, lung, breast, renal, spleen, skin, ovarian, prostate, bladder, and pancreas. The Core is always willing to develop additional new models.
Core services utilize murine models to facilitate in vivo cancer drug screening, drug evaluation and drug development. Core services include drug administration (sub-cutaneous, intravenous, intraperitoneal, prolonged slow-release silastic capsule), blood drawing (repetitive - saphenous vein, or terminal – cardiac puncture) for pharmacokinetic pharmacodynamic (PK/PD) studies, absorption distribution metabolism excretion (ADME) studies, syngeneic and xenograft tumor models, orthotopic tumor models. The goal is to help in evaluation of new pharmacologic agents by providing data on tumor growth, metastasis, angiogenesis, and gene expression. The facility also provides consultation services to assist the investigator in all aspects of animal tumor model development
| Hours | Location |
|
Monday - Friday 9 AM - 4 PM |
Health Sciences animal facilities and WG-18 Cleveland, OH 44106 |
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Mamuni Swain |
Core Manager
|
248-787-8277
|
mamuni.swain@case.edu
|
WG18
|
| William Schiemann |
Core Director
|
216-368-5763
|
william.schiemann@case.edu
|
Wood Building, 4th floor
|
