Applied Functional Genomics Core

Overview of Services

The Applied Functional Genomics Core (AFGC) offers functional genomic study design and a highly standardized, top-to-bottom platform for conducting RNA isolation, Illumina-based RNA sequencing, and bioinformatics on a wide variety of clinical sample types. We provide workflows that are optimized for many difficult sample types, such as ultra-low input (biopsies, laser capture, small cell numbers), 10X Genomics single cell-sequencing (scRNA-Seq), and Spatial RNA sequencing via 10X Genomics' Visium and Nanostring's GeoMx platforms, and our analysis tools can integrate multiple data types, whether clinical or functional, in the bioinformatics analysis to uncover biomarkers or correlates. Our advanced bioinformatics methods include pathway, network, and meta-analysis for researchers who require a look at biology across different studies, especially in correlation with clinical and immunophenotyping data.

The Applied Functional Genomics Core also serves as the assay and analytics platform for the Case Comprehensive Cancer Center's Genomics and Bioinformatics Shared Resources and the Rustbelt CFAR Biostatistics and Systems Biology Core (BSB). The CFAR BSB Core also houses the Inter-CFAR Integrated Analysis Group to support a unique partnership between the Rustbelt CFAR and the University of Miami CFAR, thus providing access to other omic technologies and meta-analysis for external CFAR members, and data integration.

*** Note that due to the cumulative and ongoing effects of the COVID-19 pandemic on personnel, support, and supply chains, the AFGC is experiencing delays in operations (10/28/2022). ***

Contacts

Hours of Operation and Location 

Shipping address

AFGC
Case Western Reserve University
2123 Adelbert Rd.
Wood Research Tower, RT100-5
Cleveland OH
44106-2624
Tel: 216-368-4662

Contacts

Map