Applied Functional Genomics Core

Overview of Services

The Applied Functional Genomics Core (AFGC) partners with the CWRU Genomics Core to offer functional genomic study design and a highly standardized, top-to-bottom platform for conducting RNA isolation, Illumina-based RNA sequencing, and advanced bioinformatics on a wide variety of clinical sample types. We provide workflows that are optimized for many difficult sample types, such as ultra-low input (biopsies, small cell numbers), and our analysis tools can integrate multiple data types, whether clinical or functional, in the bioinformatics analysis to uncover biomarkers or correlates. Our advanced bioinformatics methods include pathway and network analysis, meta-analysis, and “Mixomics” for researchers who require a look at biology across very different studies, especially in correlation with immunophenotyping data.

The Applied Functional Genomics Core also serves as the transriptomics and bioinformatic platform for the CFAR Experimental and Analytic Systems Biology Core (EASB). We therefore partner with a variety of clinical, CFAR and university cores, for those researchers who require a true top-to-bottom systems biology analysis. The EASB Core also houses the Inter-CFAR Bioinformatic Network to facilitate partnerships between CFARs (e.g. The University of Miami CFAR), providing access to other omic technologies, bioinformatic analysis and meta-analysis for external CFAR members, and data integration between CFARs.

Team 

Hours of Operation and Location