In Observance of U.S. Holiday, Martin Luther King Jr. Day, Agilent Cross Lab/ iLab Operations Software will be closed during U.S. hours on Monday January 21st, 2019. We will resume regular U.S. support hours on Tuesday January 22nd, 2018. EU and APAC Support will remain open during this time. For urgent matters, please add "Urgent" to the ticket/ email subject or press "1", when prompted, to escalate a call on the iLab Support phone and we will prioritize those requests first. Issues from the Kiosk and Interlock issues on January 18th, 2019 should be resolved now. If any issues persist, we recommend first performing a power to cycle the bridge.

Cryo-Electron Microscopy Core Facility

Cryo-EM Core Facility Services

The CWRU Cryo-EM Facility became a fee-for-service recharge facility in 2019.  we have provided a range of cryo electron microscopy services for CWRU and non-CWRU researchers. We specialize in high resolution transmission electron microscopy of frozen particulate samples, a.k.a Cryo EM.  

Cryo-EM is an ensemble of techniques allowing the observation of biological specimens in their native environment at cryogenic temperatures in EM. Investigating biomolecules at atomic resolutions allows us to explore the very architecture of life. Cryo-EM single particle analysis (SPA) is rapidly becoming a mainstream structural biology technique, facilitating the study of:

  • Dynamic biological processes
  • Protein structures
  • Protein complexes, aggregates
  • Large virus assemblies

This deeper insight enables our users to develop novel therapeutic agents faster than ever before.

The Facility offers complete conventional TEM services including sample processing, ultramicrotomy, film developing, and photographic printing, as well as immunocytochemistry. Intramural collaboration is available. We welcome trained EM users as well as researchers who wish to be trained.


Location and hours of operation

Cleveland Center for Membrane and Structural Biology (CCMSB)

1819 E 101st Street

Cleveland, OH 44106

Opened to trained users 24/7

Please Park at the back door. A permit is needed if you park at the lot before the main door.


Name Role Phone Email Location
Sudha Chakrapani

Kunpeng Li
cryo-TEM services
CCMSB 119-120
Hisashi Fujioka
conventional TEM Services
CCMSB Rm. 158

Price List

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Cryo-Electron Microscopy and Membrane Protein Analysis Services (1)