Neurodegenerative Research Core

Overview

The Neurodegenerative Research Core (NRC) provides Case Western Reserve University (CWRU) investigators and other researchers access to human tissue and bodily fluids collected from patients suspected of prion diseases such as Creutzfeldt-Jakob’s Disease (CJD) and other neurodegenerative diseases. In addition to biorepository services, the NRC offers routine histologic and special stains and immunohistochemical stains specific for neurodegenerative diseases. Lastly, the NRC offers CWRU investigators and other researchers access to instrumentation and essential reagents used to perform Real-Time Quaking-Induced Conversion (RT-QuIC) assays.

Tissue specimens and bodily fluids are available for researchers investigating the following diseases:

  • Creutzfeldt-Jakob Disease (CJD)
  • Variant Creutzfeldt-Jakob Disease (vCJD)
  • Iatrogenic Creutzfeldt-Jakob Disease (iCJD)
  • Gerstmann-Straussler-Scheinker Syndrome (GSS)
  • Fatal Familial Insomnia
  • Genetic CJD (gCJD)
  • Sporadic Fatal Insomnia
  • Variably Protease Sensitive Prionopathy
  • Other neurodegenerative conditions like Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration, etc.

Location and hours of operation

Hours Location

Monday-Friday 

8:00 - 5:00 PM

2085 Adelbert Rd Rm 419

Cleveland, Ohio 44106

 Staff and Leadership

Name Role Phone Email
Brian Appleby, MD Director 216-368-1274 bsa35@case.edu
Crystal Moskal  Administrative Manager 216-368-0819 cdm95@case.edu
Aaron Foutz Lab Manager 216-368-0656 apf28@case.edu

Links and Resources

  1. National Prion Disease Pathology Surveillance Center

Contacts

Name Role Phone Email Location
Crystal Moskal
Administration Manager
 
216-368-0819
 
Cdm95@case.edu
 

 
Aaron Foutz
Lab Manager
 
216-368-0656
 
Apf28@case.edu
 

 

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