Neurodegenerative Research Core



The Neurodegenerative Research Core (NRC) provides Case Western Reserve University (CWRU) investigators and other researchers access to human tissue and bodily fluids collected from patients suspected of prion diseases such as Creutzfeldt-Jakob’s Disease (CJD) and other neurodegenerative diseases. In addition to biorepository services, the NRC offers routine histologic and special stains and immunohistochemical stains specific for neurodegenerative diseases. Lastly, the NRC offers CWRU investigators and other researchers access to instrumentation and essential reagents used to perform Real-Time Quaking-Induced Conversion (RT-QuIC) assays.

Tissue specimens and bodily fluids are available for researchers investigating the following diseases:

  • Creutzfeldt-Jakob Disease (CJD)
  • Variant Creutzfeldt-Jakob Disease (vCJD)
  • Iatrogenic Creutzfeldt-Jakob Disease (iCJD)
  • Gerstmann-Straussler-Scheinker Syndrome (GSS)
  • Fatal Familial Insomnia
  • Genetic CJD (gCJD)
  • Sporadic Fatal Insomnia
  • Variably Protease Sensitive Prionopathy
  • Other neurodegenerative conditions like Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration, etc.

Location and hours of operation

Hours Location


8:00 - 5:00 PM

2085 Adelbert Rd Rm 419

Cleveland, Ohio 44106

 Staff and Leadership

Name Role Phone Email
Brian Appleby, MD Director 216-368-1274
Tatiana Weaver Lab Manager 216-368-1447
 Keisi Kotobelli Data Manager 216-368-5722

Links and Resources

  1. National Prion Disease Pathology Surveillance Center


Name Role Phone Email Location
Keisi Kotobelli
Data Manager
Path 419
Tatiana Weaver
Lab Manager
Path 401