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Neurodegenerative Research Core


The Neurodegenerative Research Core (NRC) provides Case Western Reserve University (CWRU) investigators and other researchers access to human tissue and bodily fluids collected from patients suspected of prion diseases such as Creutzfeldt-Jakob’s Disease (CJD) and other neurodegenerative diseases. In addition to biorepository services, the NRC offers routine histologic and special stains and immunohistochemical stains specific for neurodegenerative diseases. Lastly, the NRC offers CWRU investigators and other researchers access to instrumentation and essential reagents used to perform Real-Time Quaking-Induced Conversion (RT-QuIC) assays.

Tissue specimens and bodily fluids are available for researchers investigating the following diseases:

  • Creutzfeldt-Jakob Disease (CJD)
  • Variant Creutzfeldt-Jakob Disease (vCJD)
  • Iatrogenic Creutzfeldt-Jakob Disease (iCJD)
  • Gerstmann-Straussler-Scheinker Syndrome (GSS)
  • Fatal Familial Insomnia
  • Genetic CJD (gCJD)
  • Sporadic Fatal Insomnia
  • Variably Protease Sensitive Prionopathy
  • Other neurodegenerative conditions like Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration, etc.

Location and hours of operation

Hours Location


8:00 - 5:00 PM

2085 Adelbert Rd Rm 419

Cleveland, Ohio 44106

 Staff and Leadership

Name Role Phone Email
Brian Appleby, MD Director 216-368-1274
Crystal Moskal  Administrative Manager 216-368-0819
Aaron Foutz Lab Manager 216-368-0656

Links and Resources

  1. National Prion Disease Pathology Surveillance Center


Name Role Phone Email Location
Crystal Moskal
Administration Manager

Aaron Foutz
Lab Manager