Neurodegenerative Research Core

Overview

The Neurodegenerative Research Core (NRC) provides Case Western Reserve University (CWRU) investigators and other researchers access to human tissue and bodily fluids collected from patients suspected of prion diseases such as Creutzfeldt-Jakob’s Disease (CJD) and other neurodegenerative diseases. In addition to biorepository services, the NRC offers routine histologic and special stains and immunohistochemical stains specific for neurodegenerative diseases. Lastly, the NRC offers CWRU investigators and other researchers access to instrumentation and essential reagents used to perform Real-Time Quaking-Induced Conversion (RT-QuIC) assays.

Tissue specimens and bodily fluids are available for researchers investigating the following diseases:

• Creutzfeldt-Jakob Disease (CJD)
• Variant Creutzfeldt-Jakob Disease (vCJD)
• Iatrogenic Creutzfeldt-Jakob Disease (iCJD)
• Gerstmann-Straussler-Scheinker Syndrome (GSS)
• Fatal Familial Insomnia
• Genetic CJD (gCJD)
• Sporadic Fatal Insomnia
• Variably Protease Sensitive Prionopathy
• Other neurodegenerative conditions like Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration, etc.

Location and hours of operation

Hours	Location
Monday-Friday  9:00 - 4:30 PM	2085 Adelbert Rd Rm 419 Cleveland, Ohio 44106

 Staff and Leadership

Name	Role	Phone	Email
Brian Appleby, MD	Director	216-368-1274	bsa35@case.edu
Tatiana Weaver	Lab Manager	216-368-1447	txw545@case.edu
Keisi Kotobelli	Data Manager	216-368-5722	kxk68@case.edu

Links and Resources

1. National Prion Disease Pathology Surveillance Center

Contacts

Name	Role	Phone	Email	Location
Keisi Kotobelli	Data Manager	216-368-5722	kxk680@case.edu	Path 419
Tatiana Weaver	Lab Manager	216-368-1447	txw545@case.edu	Path 401

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