Neurodegenerative Research Core

Overview

The Neurodegenerative Research Core (NRC) provides Case Western Reserve University (CWRU) investigators and other researchers access to human tissue and bodily fluids collected from patients suspected of prion diseases such as Creutzfeldt-Jakob’s Disease (CJD) and other neurodegenerative diseases. In addition to biorepository services, the NRC offers routine histologic and special stains and immunohistochemical stains specific for neurodegenerative diseases. Lastly, the NRC offers CWRU investigators and other researchers access to essential reagents used to perform Real-Time Quaking-Induced Conversion (RT-QuIC) assays.

Tissue specimens and bodily fluids are available for researchers investigating the following diseases:

• Creutzfeldt-Jakob Disease (CJD)
• Variant Creutzfeldt-Jakob Disease (vCJD)
• Iatrogenic Creutzfeldt-Jakob Disease (iCJD)
• Gerstmann-Straussler-Scheinker Syndrome (GSS)
• Fatal Familial Insomnia
• Genetic CJD (gCJD)
• Sporadic Fatal Insomnia
• Variably Protease Sensitive Prionopathy
• Other neurodegenerative conditions like Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration, etc.

Location and hours of operation

Hours	Location
Monday-Friday  9:00 - 4:30 PM	NPDPSC 2210 Circle Drive, Robbins, East Wing Cleveland, OH 44106-4977

 Links and Resources

1. National Prion Disease Pathology Surveillance Center

Contacts

Name	Role	Phone	Email	Location
Keisi Kotobelli	Data Manager	216-368-0587	keisi.kotobelli@case.edu	Robbins, 413
Debora Poruban	Laboratory Manager	216-368-0587	debora.poruban@case.edu	Robbins, 412
Gabriella DelPrete	Tissue Coordinator	216-368-0587	gabriella.delprete@case.edu	Robbins, 413

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