ALERT

ATTENTION ⚠️

In observance of the holidays, Agilent CrossLab/iLab Operations Software Support Help Desk will be closed during U.S. hours on Monday, January 20th, 2025. We will resume regular U.S. support hours on Tuesday, January 21st, 2025. For urgent matters, please add "Urgent" to the ticket/email subject or press "1" when prompted to escalate a call on the iLab Support phone, and we will prioritize those requests first.

ALERT

Attention: The Seahorse system located in the Translational Research Shared Resource core lab (WRB 3-503) will be relocating to the Research Tower (RT-300) adjacent to the Wood Building.

The old system will be available until Dec 24 at which time Agilent will come to remove the old system. A newer model Seahorse is currently in the process of being installed. Once setup is completed, the new Seahorse will be available for reservation through the Mitochondrial Core's iLab page.

If you have any questions or concerns regarding the transition, please contact Jason Mears at jason.mears@case.edu..

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DDRCC Mouse Models Core

 

                                                                                                                     

Overview of Services

The Mouse Models Core of the Cleveland DDRCC provides members with access to a comprehensive set of services and unique mouse models to support in vivo investigations of digestive diseases involving inflammatory and metabolic processes (i.e., inflammatory bowel disease, hepatitis, obesity and metabolic syndromes). These conditions affect millions of individuals in the U.S., and facilitating their study in mouse models will help uncover key pathogenic mechanisms and develop new therapeutic approaches.

The Cleveland DDRCC Mouse Models Core can provide experimental cohorts of SAMP1/YitFc (SAMP) and TNF∆ARE mice and educate, consult, and train DDRCC investigators in the use of various mouse modeling techniques. The core can also provide high-resolution murine video endoscopy with well-validated scoring of intestinal inflammation and colonic tumors and perform stereomicroscopy on murine intestinal tissues and assess inflammation by 3-D stereomicroscopy with assessment of myeloperoxidase activity.

Product List

  • Breeding and Provision of Experimental Mice (SAMP and TNFdARE mice) 
  • Steromicroscopy 
  • Murine Endoscopy with Inflammation Scoring 
  • Consultation – Fabio Cominelli, MD, PhD 
  • Consultation – Luca Di Martino, PhD 
  • Consultation – Alexander Rodriguez-Palacios, DVM, PhD 

*** All consultation free for DDRCC members *** 

Location and hours of operation

Hours   Location

Monday - Friday

9 AM - 5 PM

  2109 Adelbert Road
  BRB 509
  Cleveland, OH 44106

Links and Resources

 Link: Mouse Models Core Website

Contacts

Name Role Phone Email Location
Tracy Krebs, MBA
Core Manager
 
216-368-6058
 
tracy.krebs@case.edu
 
Biomedical Research Building - Room 523
 
Fabio Cominelli, MD, PhD
Co-Director
 
216-844-7344
 
fabio.cominelli@case.edu
 
Biomedical Research Building - Room 524
 
Alexander Rodriguez-Palacios, DVM, PhD
Co-Director
 
216-368-8545
 
alexander.rodriguez-palacios@case.edu
 
Biomedical Research Building - Room 525
 

Service list


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