DDRCC Mouse Models Core

Overview of Services

The Mouse Models Core of the Cleveland DDRCC provides members with access to a comprehensive set of services and unique mouse models to support in vivo investigations of digestive diseases involving inflammatory and metabolic processes (i.e., inflammatory bowel disease, hepatitis, obesity and metabolic syndromes). These conditions affect millions of individuals in the U.S., and facilitating their study in mouse models will help uncover key pathogenic mechanisms and develop new therapeutic approaches.

The Cleveland DDRCC Mouse Models Core can provide experimental cohorts of SAMP1/YitFc (SAMP) and TNF∆ARE mice and educate, consult, and train DDRCC investigators in the use of various mouse modeling techniques. The core can also provide high-resolution murine video endoscopy with well-validated scoring of intestinal inflammation and colonic tumors and perform stereomicroscopy on murine intestinal tissues and assess inflammation by 3-D stereomicroscopy with assessment of myeloperoxidase activity.


  • Breeding and Provision of Experimental Mice (SAMP and TNFdARE mice) 
  • Steromicroscopy with Assessment of MPO Activity 
  • Murine Endoscopy with Inflammation Scoring 
  • Consultation – Fabio Cominelli, MD, PhD 
  • Consultation – Luca Di Martino, PhD 
  • Consultation – Alexander Rodriguez-Palacios, DVM, PhD 
  • Consultation – Natalia Aladyshkina 

All consultation free for DDRCC members


Fabio Cominelli, MD, PhD | Core Director

Alexander Rodriguez-Palalcios, PhD | Manager

Alicia DePlatchett, MBA | Core Administrator

Location and hours of operation

Hours   Location

Open:  Monday - Friday 8 AM - 4 PM

  2109 Adelbert Road
  BRB 509A
  Cleveland, OH 44106

Links and Resources

  1. Mouse Models Core Website


Name Role Phone Email Location
Alicia DePlatchett, MBA
Administrative Manager
Biomedical Research Building - Room 523
Fabio Cominelli, MD, PhD
Biomedical Research Building - Room 524
Alexander Rodriguez-Palacios, DVM, PhD
Manager of Mouse Models Core
Biomedical Research Building - Room 525