Center for Medical Mycology

Overview of Services

Research at the Center for Medical Mycology (CMM) is devoted to the following main areas:

  1. Characterization of the oral mycobiome and its relevance to oral and intestinal health
  2. Characterization of fungal biofilms and treatment options
  3. Determination of virulence factors responsible for the pathogenesis of fungi including dermatophytes, Candida albicans, Cryptococcus neoformans, Aspergillus and other systemic and opportunistic fungal pathogens
  4. Determination of the mechanism of action of different antifungal agents
  5. Molecular identification of organisms
  6. Bioinformatics services
  7. Pre-clinical studies of novel antifungals, including in vitro and in vivo testing using reference isolates from an extensive culture collection
  8. Central laboratory mycology services for national and international clinical trials

Of particular relevance in the clinical laboratory area are the microdilution methods we developed for determining the susceptibility of Cryptococcus neoformans and dermatophytes. We have shown that these methods are reproducible, easy to perform, and have both intra- and inter-laboratory agreement. Critically, we demonstrated that cryptococcal susceptibility to fluconazole is an important predictor of treatment success for patients with acute AIDS-associated cryptococcal meningitis. These methods have been adopted as part of the CLSI Reference Methods for Antifungal Susceptibility Testing.

Strong support for these research efforts are drawn from different sources including the established faculty of the Department of Dermatology, associated researchers, and newly appointed faculty of the Center for Medical Mycology at Case Western Reserve University. Existing faculty provide a wealth of expertise in clinical studies, pharmacology, immunology and molecular biology of the skin and skin diseases, and medical mycology. The presence of faculty with a wide array of multi-disciplinary expertise allows for addressing research issues from different angles.

Leadership

Location and hours of operation

Hours CMM Location Microbiome Location

Monday - Friday

8am - 5pm

11100 Euclid Avenue

Bulding: Wearn, Room: 319

Cleveland, Ohio 44106-5028

2109 Adelbert Rd.

Buliding: BRB, Room: 539

Cleveland, Ohio 44106

Links and Resources

Contacts

Name Role Phone Email Location
Robert Wyza
Clinical Research Operations Manager
 
216-983-3093
 
Robert.Wyza@case.edu
 
Wearn Rm. 307
 
Mahmoud Ghannoum
Facility Director
 
216-844-8313
 
Mahmoud.Ghannoum@case.edu
 
Wearn Rm. 311
 
Fatima Abidi
Clinical Studies
 
216-983-0877
 
Fatimazohra.Abidi@Uhhospitals.org
 
Wearn Rm. 319
 
Lisa Long
In-vitro and In-vivo Studies
 
216-983-3094
 
Lisa.Long@Uhhospitals.org
 
Wearn Rm. 303
 
Mauricio Retuerto
Microbiome Studies
 
216-368-8762
 
Mauricio.Retuerto@case.edu
 
BRB Rm. 539