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Germ-Free Mouse Models

Overview of Services

Research exploring the role of the microbiome, with particular emphasis on the gut microbiome, is growing rapidly, affecting almost every organ in the body and every discipline in biology and medicine. One very important approach to study the functionality of the gut microbiome is the use of Germ-Free (GF) Mice, which are bred in gnotobiotic facilities. The Germ Free Mouse Models Core of the Case Digestive Health Research Institute (DHRI) is housed in the Animal Resource Center (ARC) of the Biomedical Research Building (BRB) and provides a comprehensive and unique set of services for the greater research community. 

 

Services Provided:

  • Gavaging of bacteria or fecal matter
  • Intraperitoneal (IP) drug administration
  • Mouse weighing
  • Germ-free double cage husbandry
  • Organ and tissue harvest
  • Assistance in preparing IACUC protocols for individual laboratories
  • Germ-free rederivation and subsequent genotyping

 

Leadership

Fabio Cominelli, MD, PhD

Core Director

216-844-7344

fxc90@case.edu

BRB 524

Alexander Rodriguez-Palacios, DVM, PhD

Core Co-Director

216-368-8545

axr503@case.edu

BRB 525

Tracy Krebs, MBA

Core Administrative Director

216-368-6058

tls23@case.edu

BRB 523

         

Dennis Gruszka

Administrator

 

drg59@case.edu

 

Madison Bell

Administrator

 

mnb68@case.edu

 

Salem Stacey

Manager

 

Sxs2665@case.edu

 

 

 

Location and Hours of Operation

Hours Location

Monday - Friday 

8AM - 4PM 

2109 Adelbert Road 

BRB 509A

Cleveland, OH 44106

 

Links and Resources

  1. The Case DHRI

Contacts

Name Role Phone Email Location
Tracy Krebs
Core Administrative Director
 
216-368-6058
 
tls23@case.edu
 

 
Dennis Gruszka
Administrator
 

 
drg59@case.edu
 

 
Madison Bell
Administrator
 

 
mnb68@case.edu
 

 
Salem Stacey
Administrator
 

 
sxs2665@case.edu