In Observance of U.S. Holiday, Thanksgiving, Agilent Cross Lab/ iLab Operations Software Support Help Desk will be closed during U.S. hours on Thursday November 24th and Friday November 25th, 2022. We will resume regular U.S. support hours on Monday November 28th, 2022. EU and APAC Support will remain open during this time. For urgent matters, please add "Urgent" to the ticket/ email subject or press "1", when prompted, to escalate a call on the iLab Support phone and we will prioritize those requests first.

Germ-Free Mouse Models

Overview of Services

Research exploring the role of the microbiome, with particular emphasis on the gut microbiome, is growing rapidly, affecting almost every organ in the body and every discipline in biology and medicine. One very important approach to study the functionality of the gut microbiome is the use of Germ-Free (GF) Mice, which are bred in gnotobiotic facilities. The Germ Free Mouse Models Core of the Case Digestive Health Research Institute (DHRI) is housed in the Animal Resource Center (ARC) of the Biomedical Research Building (BRB) and provides a comprehensive and unique set of services for the greater research community. 


Services Provided:

  • Gavaging of bacteria or fecal matter
  • Intraperitoneal (IP) drug administration
  • Mouse weighing
  • Germ-free double cage husbandry
  • Organ and tissue harvest
  • Assistance in preparing IACUC protocols for individual laboratories
  • Germ-free rederivation and subsequent genotyping



Fabio Cominelli, MD, PhD

Core Director


BRB 524

Alexander Rodriguez-Palacios, DVM, PhD

Core Co-Director


BRB 525

Tracy Krebs, MBA

Core Administrative Director


BRB 523


Dennis Gruszka



Madison Bell



Salem Stacey





Location and Hours of Operation

Hours Location

Monday - Friday 

8AM - 4PM 

2109 Adelbert Road 

BRB 509A

Cleveland, OH 44106


Links and Resources

  1. The Case DHRI


Name Role Phone Email Location
Tracy Krebs
Core Administrative Director

Dennis Gruszka

Madison Bell

Salem Stacey