Germ-Free Mouse Models Core


Overview of Services

Research exploring the role of the microbiome, with particular emphasis on the gut microbiome, is growing rapidly, affecting almost every organ in the body and every discipline in biology and medicine. One very important approach to study the functionality of the gut microbiome is the use of Germ-Free (GF) Mice, which are bred in gnotobiotic facilities. The Germ Free Mouse Models Core of the Case Digestive Health Research Institute (DHRI) is housed in the Animal Resource Center (ARC) of the Biomedical Research Building (BRB) and provides a comprehensive and unique set of services for the greater research community. 


Product List                                                                           

  • Gavaging of bacteria or fecal matter
  • Intraperitoneal (IP) drug administration
  • Mouse weighing
  • Germ-free double cage husbandry
  • Organ and tissue collection
  • Assistance in preparing IACUC amendments regarding germ-free animal usage for individual laboratories
  • Germ-free rederivation and subsequent genotyping                                                                                                                                    

Location and Hours of Operation                                                                                                                                                                                                                            

Monday - Friday       9AM - 5PM


2109 Adelbert Road 

BRB 509A

Cleveland, OH 44106

Ph: 216-368-0756







Links and Resources

The Case DHRI





Name Role Phone Email Location
Tracy Krebs
Core Manager
BRB 523
Madison Bell
Core Staff
BRB 509A
Dennis Gruszka
Financial Manager
BRB 519
Fabio Cominelli, MD, PhD
BRB 524
Alexander Rodriguez-Palacios, DVM, PhD
BRB 525
Taliba Hodge
Core Staff
BRB 509A

Service list

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Animal Purchase (3)
Cage and Supply Charges (1)
Services (3)