Welcome!
Research exploring the role of the microbiome, with particular emphasis on the gut microbiome, is growing rapidly, affecting almost every organ in the body and every discipline in biology and medicine. One very important approach to study the functionality of the gut microbiome is the use of Germ-Free (GF) Mice, which are bred in gnotobiotic facilities. The Germ Free Mouse Models Core of the Case Digestive Health Research Institute (DHRI) is housed in the Animal Resource Center (ARC) of the Biomedical Research Building (BRB) and provides a comprehensive and unique set of services for the greater research community.
| Monday - Friday | 9AM - 5PM |
|
2109 Adelbert Road BRB 509A Cleveland, OH 44106 Ph: 216-368-0756 |
|
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Tracy Krebs |
Core Manager
|
216-368-6058
|
tracy.krebs@case.edu
|
BRB 523
|
| Madison Bell |
Core Staff
|
216-368-0756
|
madison.n.bell@case.edu
|
BRB 509A
|
| Fabio Cominelli, MD, PhD |
Co-Director
|
216-844-7344
|
fabio.cominelli@case.edu
|
BRB 524
|
| Alexander Rodriguez-Palacios, DVM, PhD |
Co-Director
|
216-368-8545
|
alexander.rodriguez-palacios@case.edu
|
BRB 525
|
| Taliba Hodge |
Core Staff
|
216-368-0756
|
taliba.hodge@case.edu
|
BRB 509A
|
| Service list |
| ► Animal Purchase (3) | |||
| Name | Description | Price | |
|---|---|---|---|
| TNFΔare (B6) |
Germ free mouse model. TNF∆ARE/+ model of Crohn’s disease (which systemically overexpresses TNFα) to generate a homozygous mutant strain that overexpress TNFα only within the intestinal epithelium. |
Inquire | |
| SAMP1/YitFc (SAMP) Mouse |
Germ free mouse model. Mice develop a spontaneous ileitis that resembles human Crohn's disease. This strain may also be useful for the study of inflammatory bowel disease (IBD). |
Internal
$170.00
each
External - Academic $170.00 each External - Foundation/Non-profit $170.00 each |
|
| C57BL/6 (C57 Black 6, B6) Mouse |
Germ free mouse model. C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Permissive background for maximal expression of most mutations. |
Internal
$150.00
each
External - Academic $150.00 each External - Foundation/Non-profit $150.00 each |
|
| ► Cage and Supply Charges (1) | |||
| Name | Description | Price | |
| Germ-Free Cage Per Diem |
Charges are per mouse cage, per day, for housing and animal husbandry services. |
Internal
$4.00
cage day
External - Academic $4.00 cage day External - Foundation/Non-profit $4.00 cage day |
|
| ► Services (3) | |||
| Name | Description | Price | |
| Consultation Request |
Germ-free Core consultation to discuss specific project needs. ( billed per hour) |
Internal
$100.00
/hr
External - Academic $100.00 /hr External - Foundation/Non-profit $100.00 /hr |
|
| Experimental Support Service |
Per hour charge for project support provided by the Germ-Free Core staff. |
Internal
$65.00
/hr
External - Foundation/Non-profit $65.00 each External - Industry $84.50 each |
|
| Germ-free Rederivation |
This process is performed through Taconic Biosciences. Please submit a request and a core member will contact you to discuss your projects needs. |
External - Academic
$9,300.00
each
External - Foundation/Non-profit $9,300.00 each |
|
