Welcome!
ALERT Event: Nanoscopy Imaging Using STED 3X Technology – Achieving Resolutions Down to 30nm (Registry Required)
Date: Friday, Nov. 22nd. Time: 11:00 AM – 12:00 PM
Location: Biomedical Research Building, Room 105
Overview:
The seminar will cover the fundamentals and capabilities of STED 3X Nanoscopy and Confocal Super-Resolution technology. STED (Stimulated Emission Depletion) allows for super-resolution imaging purely through optical means, built on a confocal platform. Using the Leica TCS SP8 system, you can achieve 30nm XY and 130nm Z resolutions in STED mode, as well as 140nm XY and 300nm Z resolutions in confocal super-resolution mode, all powered by Leica’s exclusive White Light Laser (tunable from 470–670 nm) in a single system.
Hands-On Training (Registry Required):
Following the seminar, we'll be hosting four one-hour training sessions for STED users from 1:00 PM to 5:00 PM. Due to time constraints, each session will be limited, but it's a fantastic opportunity for our local imaging community.
Please register here. We look forward to seeing you there!
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Research exploring the role of the microbiome, with particular emphasis on the gut microbiome, is growing rapidly, affecting almost every organ in the body and every discipline in biology and medicine. One very important approach to study the functionality of the gut microbiome is the use of Germ-Free (GF) Mice, which are bred in gnotobiotic facilities. The Germ Free Mouse Models Core of the Case Digestive Health Research Institute (DHRI) is housed in the Animal Resource Center (ARC) of the Biomedical Research Building (BRB) and provides a comprehensive and unique set of services for the greater research community.
| Monday - Friday | 9AM - 5PM |
|
2109 Adelbert Road BRB 509A Cleveland, OH 44106 Ph: 216-368-0756 |
|
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Tracy Krebs |
Core Manager
|
216-368-6058
|
tracy.krebs@case.edu
|
BRB 523
|
| Madison Bell |
Core Staff
|
216-368-0756
|
madison.n.bell@case.edu
|
BRB 509A
|
| Fabio Cominelli, MD, PhD |
Co-Director
|
216-844-7344
|
fabio.cominelli@case.edu
|
BRB 524
|
| Alexander Rodriguez-Palacios, DVM, PhD |
Co-Director
|
216-368-8545
|
alexander.rodriguez-palacios@case.edu
|
BRB 525
|
| Taliba Hodge |
Core Staff
|
216-368-0756
|
taliba.hodge@case.edu
|
BRB 509A
|
| Service list |
| ► Animal Purchase (3) | |||
| Name | Description | Price | |
|---|---|---|---|
| TNFΔare (B6) |
Germ free mouse model. TNF∆ARE/+ model of Crohn’s disease (which systemically overexpresses TNFα) to generate a homozygous mutant strain that overexpress TNFα only within the intestinal epithelium. |
Inquire | |
| SAMP1/YitFc (SAMP) Mouse |
Germ free mouse model. Mice develop a spontaneous ileitis that resembles human Crohn's disease. This strain may also be useful for the study of inflammatory bowel disease (IBD). |
Internal
$170.00
each
External - Academic $170.00 each External - Foundation/Non-profit $170.00 each |
|
| C57BL/6 (C57 Black 6, B6) Mouse |
Germ free mouse model. C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Permissive background for maximal expression of most mutations. |
Internal
$150.00
each
External - Academic $150.00 each External - Foundation/Non-profit $150.00 each |
|
| ► Cage and Supply Charges (1) | |||
| Name | Description | Price | |
| Germ-Free Cage Per Diem |
Charges are per mouse cage, per day, for housing and animal husbandry services. |
Internal
$4.00
cage day
External - Academic $4.00 cage day External - Foundation/Non-profit $4.00 cage day |
|
| ► Services (3) | |||
| Name | Description | Price | |
| Consultation Request |
Germ-free Core consultation to discuss specific project needs. ( billed per hour) |
Internal
$100.00
/hr
External - Academic $100.00 /hr External - Foundation/Non-profit $100.00 /hr |
|
| Experimental Support Service |
Per hour charge for project support provided by the Germ-Free Core staff. |
Internal
$65.00
/hr
External - Foundation/Non-profit $65.00 each External - Industry $84.50 each |
|
| Germ-free Rederivation |
This process is performed through Taconic Biosciences. Please submit a request and a core member will contact you to discuss your projects needs. |
External - Academic
$9,300.00
each
External - Foundation/Non-profit $9,300.00 each |
|
