Primary Cell, Biomimetic, and iPSC-derived Cell Models Core

Overview of Services

The Primary Cell, Biomimetic, and iPSC-derived Cell Models Core B team provides and develops innovative and highly informative models for the three main tissue targets of methamphetamine, cocaine, opioids, cannabis, and HIV – the brain, gut, and peripheral circulation. The models offered can be used to evaluate the impact of drugs of abuse on HIV latency and can also be established with samples derived from persons with Substance Use Disorder and HIV. These models each reflect the diversity of molecular mechanisms governing molecular and cellular responses to drugs and HIV latency in CD4 T cells from the periphery and the gut, and microglial and endothelial cells from the CNS and provide unique opportunities to contrast the effects of substance use in vivo with direct cell biological analyses ex vivo.
- iPSC-derived cortical neurons
- iPSC-derived glutamatergic neurons
- iPSC-derived microglia
- iPSC-derived astrocytes
- Tri-culture (or co-culture) of iPSC-derived neurons, astrocytes, and microglia

Leadership

Location and hours of operation

Contacts