The AFGC provides functional genomics study design and a standardized platform for RNA isolation, Illumina-based bulk, single-cell, and spatial multiomics, plus bioinformatics across diverse clinical sample types.

The Bioanalyte Core offers gene expression, protein quantification, and biomarker function analysis from various species and sample types, including tissue, serum, plasma, mucous fluids, tears, BAL fluid, and CNS.

The Histology/Imaging Core provides high-quality, cost-effective and time-efficient histological and imaging analysis of human and animal tissues of digestive inflammatory and metabolic diseases, such as inflammatory bowel disease, hepatitis, metabolic syndromes and obesity.

The CVRI Mouse Metabolic Phenotyping Core (MMPC) uses the Sable (Sable Systems International) Promethion cage system for single-mouse whole body respirometry, body weight monitoring, and continuous food intake and activity measures.

Research at the Center for Medical Mycology (CMM) is devoted to the following main areas: Fungal Susceptibility Testing, and Mycology services; and Microbiome and Cellular Services

The Chemical Engineering Instrumentation Core at Case Western Reserve aims to provide top-tier chemical identification and analysis techniques to CWRU and the greater Cleveland communities by providing access to spectroscopy, gravimetry, imaging and more.

The facility is set up to study flash-frozen samples by Cryo-EM Single-Particle Analysis (SPA), Cryo-electron Tomography (Cryo-ET) and conventional TEM services including sample processing, ultramicrotomy, film developing, and photographic printing, as well as immunocytochemistry.

The Cystic Fibrosis (CF) Mouse Models Core at Case Western Reserve University (CWRU) produces, characterizes and exports various Cystic Fibrosis Mouse Models for CF research.

The Cytometry and Microscopy Shared Resource provides access to instrumentation to perform cell-based assays and cell sorting.

The Biorepository Core procures, provides and stores DNA, serum, and biopsy and surgical tissues from patients with gastrointestinal and liver diseases as well as normal controls for use in Institutional Research Board-approved research.

The Mouse Models Core of the Cleveland DDRCC provides members with access to a comprehensive set of services and unique mouse models to support in vivo investigations of digestive diseases involving inflammatory and metabolic processes.

The Electronics Design Center (EDC) specializes in electrochemistry and microfabrication, supporting university researchers, educating students, and providing prototyping and R&D services to external organizations.

The Engineering Services Fabrication Center (ESFC) and its machine shop offer the design and fabrication of unique mechanical devices and complete systems to meet a broad range of research requirements.

The Genomics Core provides DNA/RNA sequencing using Illumina NovaSeq X Plus, NextSeq 550, and MiSeq, along with quality assessment, library prep, and BeadArray methylation and genotyping analysis.

The Germ-Free Mouse Models Core of the Case Western Reserve University Digestive Health Research Institute (DHRI) provides a comprehensive and unique set of services to explore the gut microbiome.

The HBCT Shared Resource provides services for procuring, processing, storing, analyzing, and distributing cells from human blood, bone marrow, and umbilical cords.

The Imaging Research Core provides a comprehensive suite of preclinical and clinical imaging instrumentation and techniques developed in-house by our leading imaging scientists. The core offers the expertise, infrastructure and environment that can help turn your research into a reality.

The Light Microscopy Imaging Core provides shared access to transmitted light, live-cell, confocal, multi-photon, deconvolution, super resolution, and slide scanning (brightfield and fluorescence) imaging services for the research community.

The MORE Center facilities enable a wide range of materials deposition, micro and nanoscale lithographic fabrication, structural and materials-based characterization techniques for a variety of materials and devices. This includes facilities for emerging optoelectronic technologies.

The Mitochondrial Research Core provides services to examine the composition and function of mitochondrial protein complexes. This includes functional assays that measure electron transport chain (ETC) activity in cells and in isolated complexes.

The Mouse Behavioral Phenotyping Core conducts comprehensive behavioral testing in mice, assessing motor, sensory, cognitive, emotional, and social functions tailored to investigators’ research needs.

The Neurodegenerative Research Core provides access to human tissue and bodily fluids from patients suspected of neurodegenerative diseases. It offers routine histologic and special stains and immunohistochemical stains specific for neurodegenerative diseases.

NMR Spectroscopy is a versatile technique to study the structure and dynamics of small molecules and biomacromolecules in solution, mixtures, cells, membranes, solids, or microcrystals.

The Proteomics and Small Molecule Mass Spectrometry Core services include: Structural Proteomics (Radiolytic footprinting and GEE labeling), Quantitative Proteomics (Global Phospho-Proteomics), Small Molecule Mass Spectrometry (Single Reaction Monitoring)

The Advanced RNA Profiling Core performs cutting edge, sequencing-based, transcriptomic profiling techniques, (ribosome profiling, CLIP, 3’end transcript mapping, etc.) as a full service or through a la carte services.

The SDLE Research Center focuses on materials data science, studying durability and degradation of long-lived materials through advanced characterization, accelerated aging, and high-performance computing using the CRADLE platform.

The Small Molecule Drug Development Shared Resource (SR) optimizes robust assays in 384-well format and to screen large chemical libraries to identify new small molecules for innovative cancer therapeutics.

Soft Matter Characterization Instruments include thermal analysis, molecular weight characterization, microscopy and X-ray scattering.

The Surgical Training and Research (STAR) Core provides surgical resources for education and research.

The Swagelok Center for Surface Analysis of Materials provides specialized analytical equipment with expert staff support to solve materials characterization challenges encountered in education, research and industry.

The Tissue Resources SR supports Cancer Center researchers by providing high-quality human tissues and priority histology, IHC, tissue microarray, and in situ hybridization services for human and animal samples.

Translational Research Services and Technologies offers sample handling, processing, lab analysis, preclinical drug testing, PK assays, and clinical trial study design support, along with translational and pharmacology lab resources.

bio[box] is a shared instrumentation facility with basic and advanced molecular biology instruments and microscopes. It is open to trainees, staff and faculty to use independently after sufficient training.

The Additive Manufacturing for Biotechnology Core is a resource for additive manufacture and testing of advanced biological material constructs.

The AMMRC provides advanced processing (forging/extrusion, Vacuum arc melting, Wire Arc Additive Mfg) and mechanical testing (tension, fatigue, toughness) of various materials using an array of equipment.

The Biostatistics Shared Resource provides and coordinates state-of-the-art statistical and clinical informatics research support to Case Comprehensive Cancer Center members in the design, planning, conduct, analysis and reporting of research studies.

The Cancer Metabolism Shared Resource (SR) supports investigators at the Case Comprehensive Cancer Center and across the university with isotope tracing and metabolite quantification services using GC-MS and LC-MS/MS.

The Case Metal Processing Laboratory (CMPL) collaborates with Federal Agencies, Industry, Professional Societies and Associations, National Laboratories and other Universities to promote and advance metal processing technologies by conducting cutting edge research and development.

The Chemistry Elemental Analysis User Facility offers atomic absorption spectrometers that can be used to analyze metals dissolved in aqueous solution down to parts per billion levels. These instruments are open to all users that have been trained by Department of Chemistry staff.

The Chemistry Mass Spectrometry User Facility features a new MALDI-TOF MS, two Electrospray Ion Trap MS and a GC/MS. The MALDI-TOF MS is a versatile mass spectroscopic technique with a large mass range, ideal for the analysis of anything from molecules to macromolecules, polymers and proteins.

We provide expertise in study design, data harmonization and management, complex analytics, and visualization, as well as grant and manuscript development. Our work encompasses bench, clinical, translational, and population health inquiries, with consideration for the intersection with demographics, socioeconomics, and geography.

The mission of the Integrated Genomics Shared Resource (SR) is to deliver a comprehensive spectrum of genomic technologies to the scientific community.

The Molecular Biomarker Core offers biomarker analysis including gene expression, protein quantification, and functional evaluation from diverse species and sample types such as tissue, serum, plasma, mucous fluids, and CNS.

The Population Cancer Analytics Shared Resource (PCA-SR) is Case Comprehensive Cancer Center’s centralized source of population data and analysis on cancer risk, burden, utilization, costs and outcomes. PCA-SR offers data and expertise for researchers wishing to study population-level cancer-related phenomena locally, regionally or nationally.

The Population and Quantitative Health Sciences (PQHS) Biostatistics Core provides and coordinates state-of-the-art statistical consulting and statistical research support to CWRU members in the design, planning, conduct, analysis, and reporting of research studies.

Radiation Resources equipment is available to all Case Comprehensive Cancer Center members. A range of irradiators is available to handle cells or animals at high or low dose rates.

The Synchrotron Footprinting Core provides access to instrumentation and expertise to probe the structure of biomolecules in solution using X-ray footprinting.

The Case Transgenic and Targeting Shared Resource (SR) serves the research community by generating gene-edited mice, in addition to pathogen control, cryopreservation, and other services.